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    癌基因 Oncogene -生物名詞

    放大字體  縮小字體 發(fā)布日期:2005-05-13


    其蛋白產(chǎn)品造成不可控的細(xì)胞生長(癌癥)的基因。正常細(xì)胞在細(xì)胞周期中分裂的過程是由很多基因控制的。癌基因有時(shí)產(chǎn)生于這些基因中的一個(gè)或多個(gè)突變。突變產(chǎn)生異常蛋白,不能行使正常功能調(diào)節(jié)細(xì)胞生長,或引發(fā)不可控細(xì)胞生長。癌基因也會(huì)存在于病毒,由病毒進(jìn)入宿主細(xì)胞引發(fā)癌癥,這些往往是宿主細(xì)胞的蛋白突變型


    A gene whose protein product causes uncontrolled cell growth (cancer). Normal cells divide under a very specific program called the cell cycle that is controlled by many genes. Oncogenes are sometimes produced as a result of a mutation in one or more of these genes. The mutation results in a malfunctional protein, which cannot perform its normal task to regulate cell growth or actually induces uncontrolled cell growth. Oncogenes are also found in viruses that introduce them into the host cells they infect to induce cancer; these are often mutant versions of proteins present in host cells.

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